Oxygen dependence of mitochondrial function measured by high-resolution respirometry in long-term hypoxic rats.

@article{Costa1997OxygenDO,
  title={Oxygen dependence of mitochondrial function measured by high-resolution respirometry in long-term hypoxic rats.},
  author={Lidia E. Costa and Gabriela M{\'e}ndez and Alberto E Boveris},
  journal={The American journal of physiology},
  year={1997},
  volume={273 3 Pt 1},
  pages={C852-8}
}
Respiration and oxidative phosphorylation were investigated in tightly coupled mitochondria isolated from liver and heart of rats submitted to a simulated altitude of 4,400 m for 14-15 mo and their corresponding controls at sea level. High-resolution respirometry was utilized to determine the apparent Michaelis-Menten constant for ADP and O2 (K(m)-ADP and K(m)-O2, respectively), the latter under active and resting states of mitochondrial respiration. The K(m)-O2 in mitochondria isolated from… CONTINUE READING

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