Oxygen dependence of flux control of cytochrome c oxidase -- implications for mitochondrial diseases.

@article{Wiedemann1998OxygenDO,
  title={Oxygen dependence of flux control of cytochrome c oxidase -- implications for mitochondrial diseases.},
  author={Falk R. Wiedemann and Wolfram S Kunz},
  journal={FEBS letters},
  year={1998},
  volume={422 1},
  pages={33-5}
}
The oxygen dependence of cytochrome c oxidase control on succinate oxidation was investigated in saponin-permeabilized muscle fibers and isolated mitochondria from mouse quadriceps muscle applying metabolic control analysis. For this cyanide titrations of the oxygen consumption in the presence of succinate+rotenone were performed at different oxygen concentrations in the medium. While with isolated mitochondria high flux control coefficients were detected only at oxygen concentrations close to… CONTINUE READING