Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro.

@article{Franko1987OxygenDO,
  title={Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro.},
  author={Allan Franko and Cameron J. Koch and B M Garrecht and J. Sharplin and David Hughes},
  journal={Cancer research},
  year={1987},
  volume={47 20},
  pages={5367-76}
}
Misonidazole, a 2-nitroimidazole, has been shown to form metabolically induced adducts to cellular molecules at a very high rate in the absence of oxygen, and this rate decreases substantially as the oxygen concentration increases. Thus, it has considerable potential as a marker for hypoxic, radiation resistant cells in tumors. The dependence of the rate of adduct formation (binding) on oxygen concentration was studied for EMT6/Ed, Walker 256, and Dunning R3327-AT rodent tumors and for two… CONTINUE READING

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