Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine.

@article{Hicks2007OxygenDA,
  title={Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine.},
  author={Kevin Owen Hicks and Hilary Myint and Adam Vorn Patterson and Frederik B Pruijn and Bronwyn G. Siim and Kashyap Patel and William R. Wilson},
  journal={International journal of radiation oncology, biology, physics},
  year={2007},
  volume={69 2},
  pages={560-71}
}
PURPOSE To compare oxygen dependence and tissue transport properties of a new hypoxia-activated prodrug, PR-104A, with tirapazamine, and to evaluate the implications for antitumor activity when combined with radiotherapy. METHODS AND MATERIALS Oxygen dependence of cytotoxicity was measured by clonogenic assay in SiHa cell suspensions. Tissue transport parameters were determined using SiHa multicellular layers. Spatially resolved pharmacokinetic (PK) and pharmacodynamic (PD) models were… CONTINUE READING
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