Oxygen availability limits renal NADPH-dependent superoxide production.

  title={Oxygen availability limits renal NADPH-dependent superoxide production.},
  author={Yifan Chen and Pritmohinder S Gill and William J. Welch},
  journal={American journal of physiology. Renal physiology},
  volume={289 4},
Renal oxygen tension is substantially lower in the medulla than in the cortex and is reduced in hypertensive rats, a model of oxidative stress. Expression of NADPH oxidase, the primary source for superoxide anion (O(2)(-)*) in the kidney, is elevated in hypertension. Because molecular oxygen (O(2)) is required for O(2)(-)* formation, we tested the hypothesis that renal NADPH oxidase activity is limited by low O(2). O(2)(-)* production by rat kidney tissue or cultured cells exposed to levels of… CONTINUE READING