Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro.

@article{McCay1984OxygenAC,
  title={Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro.},
  author={Paul B. McCay and Enoch K. Y. Lai and J. Lee Poyer and C M Dubose and Edward G. Janzen},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 4},
  pages={2135-43}
}
Free radical reactions involved in the metabolism of carbon tetrachloride by rat liver have been considered to be a cause of at least part of the injury resulting from exposure to this halocarbon. In an earlier study employing electron spin resonance and spin-trapping techniques, we demonstrated that trichloromethyl (13.CCl3) radicals are readily observed in rat liver microsomes metabolizing 13CCl4, and that the same radical could be shown to form in vivo in the liver of intact rats given a… CONTINUE READING