Oxygen affinity of hemoglobin solutions modified by coupling to PLP or NFPLP and the effects on tissue oxygenation.

@article{Bakker1984OxygenAO,
  title={Oxygen affinity of hemoglobin solutions modified by coupling to PLP or NFPLP and the effects on tissue oxygenation.},
  author={Joa C. Bakker and J vd Plas and Willem Karel Bleeker and A de Vries-von Rossen and Martijn Schoester and H. G. J. Brummelhuis and Johannes Antonius Loos},
  journal={Advances in experimental medicine and biology},
  year={1984},
  volume={180},
  pages={
          345-56
        }
}
A solution of hemoglobin can be considered as a plasma expander with blood-gas-transporting activity since It has colloid osmotic as well as O2 and CO2 transport properties. Animal experiments showed that stroma-free hemoglobin solutions can be infused without affecting renal function of the animals (Rabiner et al., 1967). Therefore stroma-free hemoglobin solutions may be potential blood substitutes especially in emergency situations when other sources of compatible blood are lacking. 

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