Oxygen affinity of hemoglobin and peripheral nerve degeneration in experimental diabetes.

@article{Farber1991OxygenAO,
  title={Oxygen affinity of hemoglobin and peripheral nerve degeneration in experimental diabetes.},
  author={S D Farber and Mark O. Farber and G A Brewer and Christoph Magnes and Richard G Peterson},
  journal={Journal of the neurological sciences},
  year={1991},
  volume={101 2},
  pages={204-7}
}
Peripheral neuropathy remains a major complication of diabetes. Numerous etiological theories of metabolic and/or vascular disturbances have been suggested including decreased endoneurial oxygen tension with presumed tissue hypoxia. Increases in the affinity of hemoglobin for oxygen (Hb-O2 affinity) may also produce tissue hypoxia and such Hb-O2 affinity changes have been implicated in the pathogenesis of diabetic microangiopathy. In order to test whether affinity hypoxia might contribute to… CONTINUE READING
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