Oxygen activation by cytochrome p450: a thermodynamic analysis.

Abstract

Electrode potentials for every intermediate in the cytochrome P450 cycle were estimated and evaluated by means of an oxidation state diagram. By this approach, and within the uncertainties of the approximations, the superoxide complex of cytochrome P450 at pH 7 is oxidizing: E degrees ' (P450FeO(2)2+, H+/P450FeOOH2+) = +0.93 V, and the Gibbs energy for the… (More)

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Cite this paper

@article{Koppenol2007OxygenAB, title={Oxygen activation by cytochrome p450: a thermodynamic analysis.}, author={Willem H Koppenol}, journal={Journal of the American Chemical Society}, year={2007}, volume={129 31}, pages={9686-90} }