Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans.

@article{Sigle2005OxygenAA,
  title={Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans.},
  author={Hans-Christian Sigle and Sascha Thewes and Markus Niewerth and Hans Christian Korting and Monika Sch{\"a}fer-Korting and Bernhard Hube},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={55 5},
  pages={663-73}
}
OBJECTIVES Ciclopirox is a topical antifungal agent of the hydroxypyridone class whose mode of action is poorly understood. In order to elucidate the mechanism of action of ciclopirox, we analysed the growth, cellular integrity, biochemical properties, viability and transcriptional profile of the polymorphic yeast Candida albicans following exposure to this antifungal agent. METHODS Multiple biochemical assays served to identify factors that were critical for antifungal activity and to… CONTINUE READING

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