Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain.

@article{Wagenfhr2016OxygenTW,
  title={Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain.},
  author={Lisa Wagenf{\"u}hr and Anne Karen Meyer and Lara Marrone and Alexander Storch},
  journal={Stem cells and development},
  year={2016},
  volume={25 3},
  pages={
          227-38
        }
}
Oxygen tension is an important factor controlling stem cell proliferation and maintenance in various stem cell populations with a particular relevance in midbrain dopaminergic progenitors. Further studies have shown that the oxygen-dependent transcription factor hypoxia-inducible factor 1α (HIF-1α) is involved in these processes. However, all available studies on oxygen effects in dopaminergic neuroprogenitors were performed in vitro and thus it remains unclear whether tissue oxygen tension in… CONTINUE READING
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