Oxygen-Glucose Deprivation in Mouse Astrocytes is Associated with Ultrastructural Changes in Connexin 43 Gap Junctions

@article{Beckmann2019OxygenGlucoseDI,
  title={Oxygen-Glucose Deprivation in Mouse Astrocytes is Associated with Ultrastructural Changes in Connexin 43 Gap Junctions},
  author={Anja Beckmann and Alexander Grissmer and Sandra Wolf and Johanna Recktenwald and Carola Meier},
  journal={Neuroscience},
  year={2019},
  volume={397},
  pages={67-79}
}
In the intact brain, astrocytes play an important role in a number of physiological functions like spatial buffering of potassium, maintenance of calcium homeostasis, neurotransmitter release, regulation of the cerebral blood flow, and many more. As pathophysiological events upon hypoxic-ischemic brain injury include excitotoxicity by glutamate release as well as oxidative stress, astrocytes and their gap junction-based syncytium are of major relevance for regulating the extent of resulting… CONTINUE READING