Oxygen Concentration and Pulmonary Hemodynamics in Newborn Lambs With Pulmonary Hypertension

@article{Lakshminrusimha2009OxygenCA,
  title={Oxygen Concentration and Pulmonary Hemodynamics in Newborn Lambs With Pulmonary Hypertension},
  author={Satyan Lakshminrusimha and Daniel D. Swartz and Sylvia F. Gugino and Chang-Xing Ma and Karen A Wynn and Rita M. Ryan and James A Russell and Robin Heise Steinhorn},
  journal={Pediatric Research},
  year={2009},
  volume={66},
  pages={539-544}
}
The effect of oxygen concentration on lowering pulmonary vascular resistance (PVR) during resuscitation in a model of persistent pulmonary hypertension of the newborn (PPHN) is not known. PPHN was induced in fetal lambs by ductal ligation 9 d before delivery. After delivery by cesarean section, resuscitation of PPHN lambs with 21%, 50%, or 100% O2 (n = 6 each) for 30 min produced similar decreases in PVR. Lambs were then ventilated with 50% O2 for 60 min and exposed to inhaled nitric oxide (iNO… CONTINUE READING
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