Oxygen-18 tracer studies of enzyme reactions with radical/cation diagnostic probes.

  title={Oxygen-18 tracer studies of enzyme reactions with radical/cation diagnostic probes.},
  author={L. Moe and B. Fox},
  journal={Biochemical and biophysical research communications},
  volume={338 1},
  • L. Moe, B. Fox
  • Published 2005
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
This review considers reactions of enzymes with the cyclopropanoid radical/cation diagnostic probes norcarane, 1,1-dimethylcyclopropane, and 1,1-diethylcyclopropane as elaborated by the use of 18O2 and 18OH2 to trace the origin of O-atoms incorporated during catalysis. The reactions of soluble and integral membrane diiron enzymes are summarized and compared to results obtained from cytochrome P450 studies. Norcarane proved to be an excellent substrate for the diiron enzyme toluene 4… Expand
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  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1984
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