Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.

@article{Hassan2007OxycodoneIO,
  title={Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.},
  author={H Ebrahim Hassan and Alan Lewis Myers and Insong James Lee and Andrew Coop and Natalie D. Eddington},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 9},
  pages={2494-506}
}
Previous studies suggest that P-glycoprotein (P-gp) modulates the PK/PD of many compounds including opioid agonists and chemotherapeutic agents. The objective of this study was to assess the P-gp affinity status of oxycodone, the P-gp expression, and the paclitaxel's tissue distribution in oxycodone-treated rats. P-gp ATPase assay, Caco-2 transepithelial permeability studies, and mdr1a/b (-/-) mice were used to assess the P-gp affinity status of oxycodone. P-gp expression was determined by… CONTINUE READING

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