Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir

  title={Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir},
  author={T. Nieminen and N. Hagelberg and T. Saari and M. Neuvonen and P. Neuvonen and K. Laine and K. Olkkola},
  journal={European Journal of Clinical Pharmacology},
  • T. Nieminen, N. Hagelberg, +4 authors K. Olkkola
  • Published 2010
  • Chemistry, Medicine
  • European Journal of Clinical Pharmacology
  • PurposeThis study aimed to investigate the effect of antivirals ritonavir and lopinavir/ritonavir on the pharmacokinetics and pharmacodynamics of oral oxycodone, a widely used opioid receptor agonist used in the treatment of moderate to severe pain.MethodsA randomized crossover study design with three phases at intervals of 4 weeks was conducted in 12 healthy volunteers. Ritonavir 300 mg, lopinavir/ritonavir 400/100 mg, or placebo b.i.d. for 4 days was given to the subjects. On day 3, 10 mg… CONTINUE READING
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