Oxy radicals, lipid peroxidation and DNA damage.

  title={Oxy radicals, lipid peroxidation and DNA damage.},
  author={Lawrence J Marnett},
Oxygen radicals react with polyunsaturated fatty acid residues in phospholipids resulting in the production of a plethora of products, many of them reactive toward protein and DNA. One of the most abundant carbonyl products of lipid peroxidation is malondialdehyde (MDA), which also is generated as a side-product of prostaglandin biosynthesis. It reacts with DNA to form adducts to deoxyguanosine, deoxyadenosine, and deoxycytidine. The deoxyguanosine adduct (M(1)G) has been detected in liver… CONTINUE READING
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