Oxiplex Reduces Leg Pain, Back Pain, and Associated Symptoms After Lumbar Discectomy

@article{Rhyne2012OxiplexRL,
  title={Oxiplex Reduces Leg Pain, Back Pain, and Associated Symptoms After Lumbar Discectomy},
  author={Alfred L. Rhyne and Scott L. Blumenthal and E H Frank and Ken Y. Hsu and Kee D. Kim and Jim A. Youssef and Jeffrey C. Wang and Paul M. Arnold and Mohammed Bendebba and Kathleen M. Block and Thomas G. Juarez and Richard P. Chiacchierini and Ronald J. Ehmsen and John S. Krelle and Gere diZerega},
  journal={Spine},
  year={2012},
  volume={37},
  pages={631–641}
}
Study Design. Prospective, randomized, blinded clinical trial. Objective. To evaluate effectiveness of Oxiplex gel for reduction of pain and associated symptoms after lumbar discectomy. Summary of Background Data. Oxiplex gel (carboxymethylcellulose, polyethylene oxide, and calcium) is used during discectomy to coat the surgical site for reduction of pain and symptoms after lumbar discectomy. Methods. Patients undergoing single-level lumbar discectomy performed by laminectomy or laminotomy and… 
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The data from this study confirm and extend results of 2 previous studies in Italy and the United States that reported statistically significantly greater reductions in leg pain in gel-treated patients with severe preoperative low back pain compared with patients who only underwent decompression surgery.
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TLDR
Greater degrees of tactile allodynia were demonstrated in rodents with more surgical manipulation, and neurological function, as measured by open field locomotor testing, was unaffected in laminectomy-only animals, though tactileAllodynia remained worse compared with sham animals.
The Use of a Dehydrated Amnion/Chorion Membrane Allograft in Patients Who Subsequently Undergo Reexploration after Posterior Lumbar Instrumentation
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References

SHOWING 1-10 OF 77 REFERENCES
Reduction of Radiculopathy and Pain With Oxiplex/SP Gel After Laminectomy, Laminotomy, and Discectomy: A Pilot Clinical Study
TLDR
Oxiplex/SP Gel was easy to use and safe for patients undergoing unilateral discectomy, and greater benefit in clinical outcome measures was seen in gel-treated patients, especially those with severe leg pain and weakness at baseline.
Low-back pain following surgery for lumbar disc herniation. A prospective study.
TLDR
The findings of the present small study suggest that lumbar disc herniation might be a possible cause of low-back pain.
SPORT Lumbar Intervertebral Disk Herniation and Back Pain: Does Treatment, Location, or Morphology Matter?
TLDR
Overall, leg pain improved more than back pain in both treatment groups, and this difference was maintained at 2 years for all herniation locations and morphologies.
The outcome of decompression surgery for lumbar herniated disc is influenced by the level of concomitant preoperative low back pain
TLDR
It is found that patients with more back pain showed significantly worse outcomes after decompression surgery for LDH, which fits with general clinical experience, but has rarely been quantified in the many predictor studies conducted to date.
Reduction of leg pain and lower-extremity weakness for 1 year with Oxiplex/SP gel following laminectomy, laminotomy, and discectomy.
TLDR
Oxiplex/SP Gel was easy to use and safe in patients who underwent unilateral discectomy and a greater benefit in clinical outcome measures was seen over the 12-month follow-up period in gel-treated patients.
Surgical and Nonsurgical Management of Sciatica Secondary to a Lumbar Disc Herniation: Five-Year Outcomes From the Maine Lumbar Spine Study
TLDR
For patients with moderate or severe sciatica, surgical treatment was associated with greater improvement than nonsurgical treatment at 5 years, and the relative benefit of surgery decreased over time.
Relationships between epidural fibrosis, pain, disability, and psychological factors after lumbar disc surgery
TLDR
It is indicated that epidural fibrosis may be considered as a radiological entity independent of patients’ complaints and the mini MMPI should be included in the assessment and planning of the reoperations in FBSS patients, because of the importance of psychological factors in postoperative pain and disability.
Association between peridural scar and recurrent radicular pain after lumbar discectomy: magnetic resonance evaluation. ADCON-L European Study Group.
TLDR
There is a significant association between the presence of extensive peridural scar and the occurrence of recurrent radicular pain and the probability of recurrent pain increases when scar score increases.
Efficacy of triamcinolone acetonide and bupivacaine for pain after lumbar discectomy
TLDR
Significant postoperative pain reduction and opiate requirements in the first 24 h, and significantly shortened duration of inpatient stay were achieved in the triamcinolone acetonide and bupivacaine group compared with other groups.
Outcome of Revision Discectomies Following Recurrent Lumbar Disc Herniation
TLDR
Based on patient derived outcome data using a validated instrument, revision discctomy is as efficacious as primary discectomy in selected patients.
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