Oxindole, a sedative tryptophan metabolite, accumulates in blood and brain of rats with acute hepatic failure.

@article{Carpenedo1998OxindoleAS,
  title={Oxindole, a sedative tryptophan metabolite, accumulates in blood and brain of rats with acute hepatic failure.},
  author={Raffaella Carpenedo and Guido Mannaioni and Flavio Moroni},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 5},
  pages={1998-2003}
}
Rats treated with oxindole (10-100 mg/kg i.p.), a putative tryptophan metabolite, showed decreased spontaneous locomotor activity, loss of the righting reflex, hypotension, and reversible coma. Brain oxindole levels were 0.05 +/- 0.01 nmol/g in controls and increased to 8.1 +/- 1.7 or 103 +/- 15 nmol/g after its administration at doses of 10 or 100 mg/kg i.p., respectively. To study the role that oxindole plays in the neurological symptoms associated with acute liver failure, we measured the… CONTINUE READING