Oxime carbamate--discovery of a series of novel FAAH inhibitors.

@article{Sit2010OximeCO,
  title={Oxime carbamate--discovery of a series of novel FAAH inhibitors.},
  author={S Y Sit and Charles M. Conway and Kai Z Xie and Robert L. Bertekap and Clotilde Bourin and Kevin D. Burris},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 3},
  pages={
          1272-7
        }
}
A series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (FAAH). In this Letter, the rationale behind the discovery and the biological evaluations of this novel class of FAAH inhibitors are presented. Both in vitro and in vivo results of selected targets are discussed, along with inhibition kinetics and molecular modeling studies.(1). 

From This Paper

Topics from this paper.