Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions.

@article{Bochkov2006OxidizedPS,
  title={Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions.},
  author={Valery N. Bochkov and Maria Philippova and Olga Oskolkova and Alexandra Kadl and Alexander Furnkranz and Erduan Karabeg and Taras Afonyushkin and Florian Gruber and Johannes M. Breuss and Alexander Minchenko and Diana Mechtcheriakova and Philipp Hohensinner and Kathrin Rychli and Johann Wojta and Th{\'e}r{\`e}se J. Resink and P. Erne and Bernd R. Binder and Norbert Leitinger},
  journal={Circulation research},
  year={2006},
  volume={99 8},
  pages={
          900-8
        }
}
Angiogenesis is a common feature observed in advanced atherosclerotic lesions. We hypothesized that oxidized phospholipids (OxPLs), which accumulate in atherosclerotic vessels can stimulate angiogenesis. We found that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) stimulated the formation of sprouts from endothelial cell spheroids and promoted growth of capillaries into Matrigel plugs in mice. OxPLs stimulated expression of vascular endothelial growth factor (VEGF) in… CONTINUE READING

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