Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo.

@article{Knapp2007OxidizedPI,
  title={Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo.},
  author={Sylvia Knapp and Ulrich Matt and Norbert Leitinger and Tom van der Poll},
  journal={Journal of immunology},
  year={2007},
  volume={178 2},
  pages={
          993-1001
        }
}
Oxidized phospholipids that are generated during inflammation exert anti-inflammatory properties and prevent death during murine endotoxemia. Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) inhibits the interaction of LPS with LPS-binding protein and CD14. In this study, we determined the functional properties of OxPAPC and potential interference with CD14 during abdominal sepsis caused by Escherichia coli. Administration of OxPAPC rendered mice highly susceptible to… CONTINUE READING

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