Oxidized phospholipids in minimally modified low density lipoprotein induce apoptotic signaling via activation of acid sphingomyelinase in arterial smooth muscle cells.

@article{Loidl2003OxidizedPI,
  title={Oxidized phospholipids in minimally modified low density lipoprotein induce apoptotic signaling via activation of acid sphingomyelinase in arterial smooth muscle cells.},
  author={Alexandra Loidl and Eva Sevcsik and Gernot Riesenhuber and Hans-Peter Deigner and Albin Hermetter},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 35},
  pages={32921-8}
}
Oxidized phospholipids, including 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), typically present in minimally modified low density lipoprotein, have been found in atherosclerotic lesions. These compounds are gaining increasing importance as inducers of different cellular responses (inflammation, proliferation, or cell death). It was the aim of this study to understand their impact on intracellular signal… CONTINUE READING