Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction.

@article{Leibundgut2012OxidizedPA,
  title={Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction.},
  author={Gregor Leibundgut and Kiyohito Arai and Alexina Orsoni and Huiyong Yin and Corey Anthony Scipione and Elizabeth R. Miller and Marlys L Koschinsky and Martin John Chapman and Joseph L. Witztum and Sotirios Tsimikas},
  journal={Journal of the American College of Cardiology},
  year={2012},
  volume={59 16},
  pages={
          1426-37
        }
}
OBJECTIVES This study sought to assess whether plasminogen, which is homologous to lipoprotein (a) [Lp(a)], contains proinflammatory oxidized phospholipids (OxPL) and whether this has clinical relevance. BACKGROUND OxPL measured on apolipoprotein B-100 (OxPL/apoB), primarily reflecting OxPL on Lp(a), independently predict cardiovascular disease (CVD) events. METHODS The authors examined plasminogen from commercially available preparations and plasma from chimpanzees; gorillas; bonobos… CONTINUE READING
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