Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication.

@article{Isakson2006OxidizedPA,
  title={Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication.},
  author={Brant E Isakson and Gerhard Kronke and Alexandra Kadl and Norbert Leitinger and Brian R. Duling},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2006},
  volume={26 10},
  pages={2216-21}
}
OBJECTIVE In endothelial cells (EC) and vascular smooth muscle cells (VSMC) from atherosclerotic mice, connexin (Cx) expression becomes distorted. Lipoprotein-derived phospholipid oxidation products (OxPAPC) play a critical role in atherosclerosis, and we hypothesized that they may act as trigger molecules causing the changes in connexin expression… CONTINUE READING