Oxidized phosphatidylcholines facilitate phospholipid flip-flop in liposomes.

  title={Oxidized phosphatidylcholines facilitate phospholipid flip-flop in liposomes.},
  author={Roman Volinsky and Lukasz Cwiklik and Piotr Jurkiewicz and Martin Hof and Pavel Jungwirth and Paavo K. J. Kinnunen},
  journal={Biophysical journal},
  volume={101 6},
Lipid asymmetry is a ubiquitous property of the lipid bilayers in cellular membranes and its maintenance and loss play important roles in cell physiology, such as blood coagulation and apoptosis. The resulting exposure of phosphatidylserine on the outer surface of the plasma membrane has been suggested to be caused by a specific membrane enzyme, scramblase, which catalyzes phospholipid flip-flop. Despite extensive research the role of scramblase(s) in apoptosis has remained elusive. Here, we… CONTINUE READING
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