Oxidized phagosomal NOX2 is replenished from lysosomes


In dendritic cells, the NADPH oxidase 2 (NOX2) is recruited to the phagosomal membrane during antigen uptake. NOX2 produces reactive oxygen species (ROS) in the lumen of the phagosome which kill ingested pathogens, delay antigen breakdown and alter the peptide repertoire for presentation to T cells. How the integral membrane component of NOX2, cytochrome… (More)


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@inproceedings{Dingjan2017OxidizedPN, title={Oxidized phagosomal NOX2 is replenished from lysosomes}, author={Ilse Dingjan and Peter T A Linders and Luuk van den Bekerom and Maksim V. Baranov and Partho Halder and Martin B.A. ter Beest and Geert van den Bogaart}, year={2017} }