Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells.

@article{Yamada2008OxidizedLD,
  title={Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells.},
  author={Yuko Yamada and Jane Tian and Yanqin Yang and Roy G. Cutler and Tinghuai Wu and Richard S. Telljohann and Mark P. Mattson and James T. Handa},
  journal={Journal of neurochemistry},
  year={2008},
  volume={105 4},
  pages={1187-97}
}
The accumulation of apolipoprotein B100 lipoproteins in Bruch membrane is an early event thought to promote age-related macular degeneration (AMD). Immunohistochemistry using an anti-oxidized low density lipoprotein antibody on 10 AMD specimens showed staining in Bruch membrane including basal deposits, a marker of AMD. To determine whether retinal pigmented epithelial cells develop a pathologic phenotype after interaction with lipoproteins, ARPE-19 cells were exposed to low density… CONTINUE READING
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