Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2.

@article{Lee2014OxidizedLL,
  title={Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2.},
  author={Ha Young Lee and Eunseo Oh and Sang Doo Kim and Jeong Kon Seo and Yoe-Sik Bae},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={443 3},
  pages={1003-7}
}
The increased level of LDL and its modification into oxLDL has been regarded as an important risk factor for the development of cardiovascular diseases such as atherosclerosis. Although some scavenger receptors including CD36 and RAGE have been considered as target receptors for oxLDL, involvement of other receptors should be investigated for oxLDL-induced pathological responses. In this study, we found that oxLDL-induced foam cell formation was inhibited by formyl peptide receptor 2 (FPR2… CONTINUE READING