Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cells.

@article{Holvoet2006OxidizedLL,
  title={Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cells.},
  author={Paul Holvoet and Penelope C Davey and Dieuwke De Keyzer and Mory Doukour{\'e} and Els Deridder and Marie-Luce Bochaton-Piallat and Giulio Gabbiani and Emmanuel Beaufort and Karine Bishay and Nancy Andrieux and Nora Benhabiles and G{\'e}rard Marguerie},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2006},
  volume={26 7},
  pages={1558-65}
}
BACKGROUND Oxidized low-density lipoprotein (LDL) is associated with cardiovascular disease. Macrophages contribute to LDL oxidation, and oxidized LDL (oxLDL) affects macrophage function. We searched for the strongest gene correlates of oxLDL in macrophages in coronary plaques and studied the effect of oxLDL on their expression in THP-1 cells. METHODS AND… CONTINUE READING