Oxidized low-density lipoprotein biomarkers in atherosclerosis.

  title={Oxidized low-density lipoprotein biomarkers in atherosclerosis.},
  author={Sotirios Tsimikas},
  journal={Current atherosclerosis reports},
  volume={8 1},
The concept that the oxidation of lipoproteins is central in the pathogenesis of atherosclerosis was first reported over 25 years ago, initially by in vitro studies and subsequently through experimental models of atherosclerosis. The innate immune system plays a key role in atherogenesis as manifested by its atherosclerosis-modulating properties, the immunogenicity of oxidized low-density lipoprotein (LDL), and the presence of oxidized LDL autoantibodies in plasma and lesions of humans. In the… CONTINUE READING

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