Oxidized lipoprotein lipids and atherosclerosis

@article{Ahotupa2017OxidizedLL,
  title={Oxidized lipoprotein lipids and atherosclerosis},
  author={Markku O. Ahotupa},
  journal={Free Radical Research},
  year={2017},
  volume={51},
  pages={439 - 447}
}
  • M. Ahotupa
  • Published 3 April 2017
  • Biology
  • Free Radical Research
Abstract Plasma lipoproteins contain variable amounts of lipid oxidation products (LOP), which are known to impair normal physiological functions and stimulate atherosclerotic processes. Recent evidence indicates that plasma lipoproteins are active carriers of LOP, low-density lipoprotein (LDL) directing transport toward peripheral tissues, and high-density lipoprotein (HDL) being active in the reverse transport. It has been proposed that the lipoprotein-specific transport of LOP could play a… 
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References

SHOWING 1-10 OF 74 REFERENCES
Translation of High-Density Lipoprotein Function Into Clinical Practice: Current Prospects and Future Challenges
TLDR
The best known of the potentially antiatherogenic functions of HDLs is their ability to promote cholesterol efflux from cells, including that from macrophages in the arterial wall, and HDL-C is an inadequate surrogate measure for the most heralded of HDL functions.
High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein.
Lipoprotein-specific transport of circulating lipid peroxides
TLDR
It is proposed that the specific atherosclerosis-related effects of serum lipoproteins are not explained by cholesterol transport alone and may rather result from the transport of the more directly atherogenic lipid peroxides.
Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL.
High Density Lipoprotein Level is Negatively Associated With the Increase of Oxidized Low Density Lipoprotein Lipids After a Fatty Meal
TLDR
Results of the present study show that HDL is associated with the postprandial appearance of lipid peroxides in LDL, and it is likely that the sequestration and transport of atherogenic lipidPeroxides is another significant mechanism contributing to cardioprotection by HDL.
High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.
TLDR
The data show that HDL is the principal vehicle for circulating plasma lipid hydroperoxides and suggest that HDL lipids may be more rapidly oxidized than those in LDL in vivo, and could imply a possible beneficial role of HDL by attenuating the build-up of oxidized lipids in LDL.
Oxidized lipids: The two faces of vascular inflammation
  • K. Birukov
  • Biology
    Current atherosclerosis reports
  • 2006
TLDR
A group of bioactive components of oxidized phospholipids with barrier-protective effects towards endothelial cells in the models of agonist-induced endothelial permeability and lipopolysaccharide-induced lung dysfunction are characterized.
Role of oxidative modifications in atherosclerosis.
TLDR
An "oxidative response to inflammation" model is proposed as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis.
...
...