Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss.

@article{Graham2009OxidizedLE,
  title={Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss.},
  author={L. Stephen Graham and Farhad Parhami and Yin Tintut and Christina M R Kitchen and Linda L. Demer and Rita B. Effros},
  journal={Clinical immunology},
  year={2009},
  volume={133 2},
  pages={265-75}
}
Osteoporosis is a systemic disease that is associated with increased morbidity, mortality and health care costs. Whereas osteoclasts and osteoblasts are the main regulators of bone homeostasis, recent studies underscore a key role for the immune system, particularly via activation-induced T lymphocyte production of receptor activator of NFkappaB ligand (RANKL). Well-documented as a mediator of T lymphocyte/dendritic cell interactions, RANKL also stimulates the maturation and activation of bone… CONTINUE READING