Oxidized lipids: The two faces of vascular inflammation

@article{Birukov2006OxidizedLT,
  title={Oxidized lipids: The two faces of vascular inflammation},
  author={Konstantin G Birukov},
  journal={Current Atherosclerosis Reports},
  year={2006},
  volume={8},
  pages={223-231}
}
  • K. Birukov
  • Published 1 May 2006
  • Biology
  • Current Atherosclerosis Reports
Elevated plasma levels of low-density lipoprotein and generation of oxidized low-density lipoprotein have been directly associated with the pathogenesis of atherosclerosis, and lipid oxidation products have been directly linked with induction and propagation of monocytic subendothelial accumulation and other inflammatory reactions associated with chronic vascular inflammation. However, accumulating data suggest that oxidized lipids may also exhibit anti-inflammatory potential and serve as… 
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Oxidized phospholipids in control of inflammation and endothelial barrier
Oxidized Phospholipids in Control of Endothelial Barrier Function: Mechanisms and Implication in Lung Injury
TLDR
Signaling and cytoskeletal mechanisms involved in OxPLs-mediated damage, rescue, and restoration of endothelial barrier in various pathophysiological settings are summarized and a future potential of OxPAPC in treating lung disorders associated with endothelial Barrier dysfunction is discussed.
Lipid mediators in the regulation of endothelial barriers
TLDR
The role of oxidized phospholipids in control of vascular endothelial barrier, agonist induced EC permeability, inflammation, and barrier recovery related to clinical settings of acute lung injury and inflammatory vascular leak is focused on.
Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis.
Inflammatory profile of oxidized phospholipids.
TLDR
The inflammatory properties of OxPL are discussed together with the underlying receptor, signalling and transcriptional mechanisms to suggest that, in addition to the proatherogenic and proinflammatory effects, OxPL can stimulate antiinflammatory and tissue-protective mechanisms.
Oxidized lipoprotein lipids and atherosclerosis
TLDR
An overview of the present knowledge of lipoprotein LOP transport and its association with the risk of atherosclerosis and cardiovascular diseases (CVD) is given and the proposed lipo-specific transport function would affect conception of the etiology of Atherosclerosis, but would not conflict current views of the pathophysiological mechanisms.
Lipid Oxidation Products on Inflammation-Mediated Hypertension and Atherosclerosis: A Mini Review
TLDR
This review aims to summarize the current evidence of lipid oxidation products on hypertension and atherosclerosis via inflammatory pathway, and toxic lipid oxidation Products such as malondialdehyde and 4-hydroxy-2-nonenal are taken into account.
Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection.
Oxidized low-density lipoprotein.
TLDR
Until its pathophysiological significance, and how it is generated in vivo are determined, the nature of its true identity will be only of classical interest.
Mediators of Vascular Inflammation
TLDR
Recent advances in the understanding of the mechanisms of vascular inflammation are described, showing that vascular inflammation can be limited by anti-inflammatory counter regulatory mechanisms that maintain the integrity and homeostasis of the vascular wall.
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References

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