Oxidized glutathione stimulated the amyloid formation of alpha-synuclein.

  title={Oxidized glutathione stimulated the amyloid formation of alpha-synuclein.},
  author={Seung R Paik and Daekyun Lee and H Cho and Eui-Nam Lee and C Chang},
  journal={FEBS letters},
  volume={537 1-3},
alpha-Synuclein is the major filamentous constituent of Lewy bodies found in Parkinson's disease (PD). The amyloid formation of alpha-synuclein was significantly facilitated by oxidized glutathione (GSSG) as the lag period of the aggregation kinetics was shortened by 2.5-fold from its absence. Reduced glutathione (GSH), on the other hand, did not influence the lag phase although it increased the final amyloid formation. The GSSG stimulation was specific for not only alpha-synuclein but also its… CONTINUE READING