Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat.

@article{Mitsumoto2001OxidizedFO,
  title={Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat.},
  author={Atsushi Mitsumoto and Yasuhito Nakagawa and Akira Takeuchi and Katsuya Okawa and Akihiro Iwamatsu and Yasukazu Takanezawa},
  journal={Free radical research},
  year={2001},
  volume={35 3},
  pages={301-10}
}
We previously found hydroperoxide-responsive proteins (HPRPs), which are comprised of peroxiredoxin I (Prx I), Prx II, Prx III, Prx VI, HSP27, G3PDH and two unidentified proteins (HPRP-2' and HPRP-5'), in human umbilical vein endothelial cells. It was demonstrated by two-dimensional polyacrylamide gel electrophoresis (2D PAGE) that most HPRPs are converted into variants with lower pI upon exposure to hydroperoxides. In this study, we examined the HPRP response on 2D gels upon exposure of human… CONTINUE READING
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