Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress.

@article{Heinecke2002OxidizedAA,
  title={Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress.},
  author={Jay W. Heinecke},
  journal={Free radical biology & medicine},
  year={2002},
  volume={32 11},
  pages={1090-101}
}
Oxidized low-density lipoprotein (LDL) is implicated in atherogenesis, but the mechanisms that oxidize LDL in the human artery wall have proven difficult to identify. A powerful investigative approach is mass spectrometric quantification of the oxidized amino acids that are left in proteins by specific oxidation reactions. Comparison of these molecular fingerprints in biological samples with those produced in proteins by various in vitro oxidation systems can indicate which biochemical pathway… CONTINUE READING

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