Oxidized LDLs Inhibit TLR-induced IL-10 Production by Monocytes: A New Aspect of Pathogen-Accelerated Atherosclerosis

@inproceedings{Bzowska2012OxidizedLI,
  title={Oxidized LDLs Inhibit TLR-induced IL-10 Production by Monocytes: A New Aspect of Pathogen-Accelerated Atherosclerosis},
  author={Małgorzata Bzowska and Anna Nogie{\'c} and Joanna E Skrzeczyńska-Moncznik and Barbara Mickowska and Krzysztof M Guzik and Juliusz R Pryjma},
  booktitle={Inflammation},
  year={2012}
}
It is widely accepted that oxidized low-density lipoproteins and local infections or endotoxins in circulation contribute to chronic inflammatory process at all stages of atherosclerosis. The hallmark cells of atherosclerotic lesions—monocytes and macrophages—are able to detect and integrate complex signals derived from lipoproteins and pathogens, and respond with a spectrum of immunoregulatory cytokines. In this study, we show strong inhibitory effect of oxLDLs on anti-inflammatory interleukin… CONTINUE READING
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