Oxidized LDL-containing immune complexes induce Fc gamma receptor I-mediated mitogen-activated protein kinase activation in THP-1 macrophages.

@article{Huang1999OxidizedLI,
  title={Oxidized LDL-containing immune complexes induce Fc gamma receptor I-mediated mitogen-activated protein kinase activation in THP-1 macrophages.},
  author={Yan Huang and Ariel Jaffa and Satu Koskinen and Asako Takei and Maria F. Lopes-Virella},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 7},
  pages={1600-7}
}
Our previous studies have shown that Fc gamma receptor (FcgammaR)-mediated uptake of LDL-containing immune complexes (oxLDL-ICs) by human monocyte-derived macrophages leads to not only transformation of macrophages into foam cells but also macrophage activation and release of cytokines. It has been shown that cross-linking of FcgammaR triggers activation of signal transduction pathways that alter gene expression in macrophages. In this study, we determined whether engagement of FcgammaR by… CONTINUE READING