Oxidized LDL Receptor 1 (OLR1) as a Possible Link between Obesity, Dyslipidemia and Cancer

@inproceedings{Khaidakov2011OxidizedLR,
  title={Oxidized LDL Receptor 1 (OLR1) as a Possible Link
                    between Obesity, Dyslipidemia and Cancer},
  author={Magomed Khaidakov and Sona Mitra and Bum-Yong Kang and Xianwei Wang and Susan Kadlubar and Giuseppe Novelli and Vinay Raj and Maria Winters and Weleetka C. Carter and Jawahar Lal Mehta},
  booktitle={PloS one},
  year={2011}
}
Recent studies have linked expression of lectin-like ox-LDL receptor 1 (OLR1) to tumorigenesis. We analyzed microarray data from Olr1 knockout (KO) and wild type (WT) mice for genes involved in cellular transformation and evaluated effects of OLR1 over-expression in normal mammary epithelial cells (MCF10A) and breast cancer cells (HCC1143) in terms of gene expression, migration, adhesion and transendothelial migration. Twenty-six out of 238 genes were inhibited in tissues of OLR1 KO mice; the… CONTINUE READING

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