Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.

@article{Murgia1993OxidizedAA,
  title={Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.},
  author={Marta Murgia and Stefania Hanau and Paola Pizzo and Mario Rippa and Francesco Di Virgilio},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 11},
  pages={8199-203}
}
The effects of oxidized ATP (oATP) on responses triggered by extracellular adenosine 5'-triphosphate (ATPe) were investigated in the mouse macrophage-like cell line J774. ATPe induced in this cell line two kinds of responses mediated by two different P2 purinergic receptors: 1) an early permeabilization of the plasma membrane to extracellular hydrophilic markers of M(r) up to 900 mediated by P2Z receptors; and 2) a fast mobilization of Ca2+ from intracellular stores mediated by P2Y receptors… CONTINUE READING
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