Oxidized, deaminated cytosines are a source of C --> T transitions in vivo.

@article{Kreutzer1998OxidizedDC,
  title={Oxidized, deaminated cytosines are a source of C --> T transitions in vivo.},
  author={D A Kreutzer and John M Essigmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 7},
  pages={3578-82}
}
The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the oxidized lesion(s) that gives rise to this mutation, the mutagenicity of three oxidized cytosines, 5-hydroxycytosine, 5-hydroxyuracil, and uracil glycol, were investigated in Escherichia coli. An M13 viral genome was constructed to contain a single oxidized cytosine at a specific site. Replication in vivo of the single-stranded genomes yielded mutation frequencies of 0… CONTINUE READING

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