Oxidatively modified proteins in aging and disease.

  title={Oxidatively modified proteins in aging and disease.},
  author={Myron Flint Beal},
  journal={Free radical biology & medicine},
  volume={32 9},
There is a large body of evidence implicating oxidative damage in the pathogenesis of both normal aging and neurodegenerative diseases. Oxidative damage to proteins has been well established. Although there are a large number of potential oxidative modifications only a few have been systematically studied. The most frequently studied marker of oxidative damage to proteins is protein carbonyl groups. 3-Nitrotyrosine is thought to be a relatively specific marker of oxidative damage mediated by… CONTINUE READING
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