Oxidatively generated complex DNA damage: tandem and clustered lesions.

@article{Cadet2012OxidativelyGC,
  title={Oxidatively generated complex DNA damage: tandem and clustered lesions.},
  author={Jean Cadet and J L Ravanat and Marisa TavernaPorro and Herv{\'e} Menoni and Dimitar Angelov},
  journal={Cancer letters},
  year={2012},
  volume={327 1-2},
  pages={5-15}
}
There is an increasing interest for oxidatively generated complex lesions that are potentially more detrimental than single oxidized nucleobases. In this survey, the recently available information on the formation and processing of several classes of complex DNA damage formed upon one radical hit including mostly hydroxyl radical and one-electron oxidants is critically reviewed. The modifications include tandem base lesions, DNA-protein cross-links and intrastrand (purine 5',8-cyclonucleosides… CONTINUE READING
58 Citations
198 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 198 references

Mechanism of neocarzinostatin action: role of DNA microstructure in determination of chemistry of bistranded oxidative damage

  • I. H. Goldberg
  • Acc. Chem. Res. 24
  • 1991
Highly Influential
6 Excerpts

Free-Radical-Induced DNA Damage and its Repair

  • C. von Sonntag
  • A Chemical Perspective,
  • 2006
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…