Oxidative stress up-regulates IL-8 and TNF-alpha synthesis by human dendritic cells.

@article{Verhasselt1998OxidativeSU,
  title={Oxidative stress up-regulates IL-8 and TNF-alpha synthesis by human dendritic cells.},
  author={Val{\'e}rie Verhasselt and Michel Goldman and F. Th. C. Willems},
  journal={European journal of immunology},
  year={1998},
  volume={28 11},
  pages={3886-90}
}
In addition to their damaging effects, reactive oxygen intermediates exert a regulatory role on gene expression and cell apoptosis. In this study, we evaluated the effects of oxidative stress on human dendritic cells (DC), a cell type which is critical for the initiation of the immune response. For this purpose, we tested the effects of H2O2 on DC derived from adherent peripheral blood mononuclear cells cultured in the presence of granulocyte-macrophage colony-stimulating factor and IL-4… CONTINUE READING
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