Oxidative stress underlies the mechanism for Ca(2+)-induced permeability transition of mitochondria.

@article{Kanno2004OxidativeSU,
  title={Oxidative stress underlies the mechanism for Ca(2+)-induced permeability transition of mitochondria.},
  author={Tomoko Kanno and Eisuke E Sato and Shikibu Muranaka and Hirofumi Fujita and Takuzo Fujiwara and Toshihiko Utsumi and Masayasu Inoue and Kozo Utsumi},
  journal={Free radical research},
  year={2004},
  volume={38 1},
  pages={27-35}
}
Recent studies demonstrated that the generation of intracellular reactive oxygen species (ROS) was enhanced prior to the onset of mitochondrial membrane permeability transition (MPT), a critical step for the induction of DNA fragmentation and apoptosis. Although Ca2+ induces typical MPT that involves depolarization and swelling of mitochondria and finally… CONTINUE READING