Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma.

@article{Kusmartsev2008OxidativeSR,
  title={Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma.},
  author={Sergei Kusmartsev and Evgeniy B Eruslanov and Hubert K{\"u}bler and Timothy Y. Tseng and Yoshihisa Sakai and Zhen Bo Su and Sergei Kaliberov and Axel Heiser and Charles J Rosser and Philip Dahm and Dietmar W. Siemann and Johannes W G Vieweg},
  journal={Journal of immunology},
  year={2008},
  volume={181 1},
  pages={346-53}
}
Metastatic renal cell carcinoma (RCC) associates with overproduction of vascular endothelial growth factor (VEGF) due to the mutation/inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. Herein we demonstrate that implantation of human RCC tumor cells into athymic nude mice promotes the appearance of VEGF receptor 1 (VEGFR1)/CD11b double-positive myeloid cells in peripheral blood. Avastin-mediated VEGF neutralization was capable of significantly reducing the numbers of circulating… CONTINUE READING

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