Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis.

@article{Lockman2012OxidativeSR,
  title={Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis.},
  author={Khalida Ann Lockman and James P Baren and Christopher J. Pemberton and Hussam Baghdadi and Karl E. V. Burgess and Nikolas Plevris-Papaioannou and Patricia Lee and Forbes A. Howie and Geoff J. Beckett and Anne Pryde and Alan J Jaap and P C Hayes and C{\'e}line Filippi and J N Plevris},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2012},
  volume={32 7},
  pages={1079-92}
}
BACKGROUND/AIMS There is still debate about the relationship between fat accumulation and mitochondrial function in nonalcoholic fatty liver disease. It is a critical question as only a small proportion of individuals with steatosis progress to steatohepatitis. In this study, we focused on defining (i) the effects of triglyceride accumulation and reactive oxygen species (ROS) on mitochondrial function (ii) the contributions of triglyceride, ROS and subsequent mitochondrial impairment on the… CONTINUE READING