Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae.

  title={Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae.},
  author={Elisa Cabiscol and E Piulats and Pedro Echave and Enrique Montero Herrero and Joaquim Ros},
  journal={The Journal of biological chemistry},
  volume={275 35},
We have analyzed the proteins that are oxidatively damaged when Saccharomyces cerevisiae cells are exposed to stressing conditions. Carbonyl groups generated by hydrogen peroxide or menadione on proteins of aerobically respiring cells were detected by Western blotting, purified, and identified. Mitochondrial proteins such as E2 subunits of both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, aconitase, heat-shock protein 60, and the cytosolic fatty acid synthase (alpha subunit… CONTINUE READING
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