Oxidative stress promotes endothelial cell apoptosis and loss of microvessels in the spontaneously hypertensive rats.

@article{Kobayashi2005OxidativeSP,
  title={Oxidative stress promotes endothelial cell apoptosis and loss of microvessels in the spontaneously hypertensive rats.},
  author={Nobuhiko P. Kobayashi and Frank A. DeLano and Geert W Schmid-Sch{\"o}nbein},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 10},
  pages={2114-21}
}
OBJECTIVE Endothelial cell apoptosis caused by oxidative stress may lead to the loss of microvessels (rarefaction) in hypertension. We examine here the effects of antioxidants on cell apoptosis and rarefaction. METHODS AND RESULTS The juvenile spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were treated with superoxide scavengers, Tempol or Tiron, during growth. After the treatment, oxidative stress status, endothelial cell apoptosis rate, and microvessel length… CONTINUE READING
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